THC-P Explained: Effects, Potency & How It Compares to THC

Cannabinoids are a fascinating group of naturally occurring compounds in the cannabis plant, each offering its own effects and potential benefits. While household names like THC and CBD have long taken center stage, ongoing research continues to uncover lesser-known cannabinoids with unique properties. Among these rare discoveries is tetrahydrocannabiphorol (THCP) — a newcomer drawing attention for its remarkable potency and intriguing possibilities. In this guide, we’ll cover everything you need to know about THCP, from its discovery and molecular structure to its potential effects, uses, and how it compares to other cannabinoids.

THCP is a naturally occurring phytocannabinoid found in trace amounts in cannabis plants. Chemically, it’s very similar to THC, but with a slightly longer side chain in its molecular structure. This small difference may significantly increase how it interacts with receptors in the body.

THC-P, or tetrahydrocannabiphorol, was discovered in 2019 by a team of Italian researchers who were able to isolate and synthesize the cannabinoid for in-vitro testing. Naturally occurring within hemp or cannabis plants, the Italian researchers received a medical cannabis varietal called “FM2”, provided by the Military Chemical Pharmaceutical Institute of Florence. Carefully isolated, characterized, and confirmed with synthesization, the FM2 cannabis gave way to two new cannabinoids, THC-P and CBDP. With in-vitro tests showing that THC-P had a binding affinity to the CB1 receptors, up to 33 times stronger than traditional delta-9 THC, these findings could help explain the variance in effects and why some strains with equal THC concentrations feel stronger than one another. Just like many of the other alternative cannabinoids, many are wondering if tetrahydrocannabiphorol can be applied to the recreational or medical fields of cannabis use.

With 7 carbon atoms on the alkyl side chain versus the 5 on delta-9 THC, scientists suspect the elongated tail is the potential cause for the high binding affinity. Keep in mind, binding affinity does not necessarily equate to strength of effects, but it does point in that direction. Those that have tried THCP have anecdotally reported that the effects of THCP and delta-9 THC are very similar, with THCP being more pronounced. This encompasses the alleged positive effects like euphoria, relaxation, nausea relief, but also may magnify the side effects like dry mouth, paranoia, and anxiety. As THC-P is relatively new, there is very little-to-no research on this cannabinoid. Found in less than 1% concentrations within hemp and cannabis plants, THCP must be made artificially, just like delta-8, THC-V, and other alt-cannabinoids that have appeared in recent years.

Some products that we carry on our online vape shop contain THC-P. Mainly found in blends, THC-P’s potential strength alone can be uncomfortably intense for users.

One product we carry is the Delta Extrax Platinum Delta-8 + THC-P Cartridge. This 1 gram 510 vape cartridge is filled with delta 8 ,THC-P, and terpenes to create a complementary blend that may aid in relaxation, creativity, and more. Perfect for those that do not like disposable vape pens, this cartridge can be screwed onto a 510 battery for immediate enjoyment.

Another similar blend comes from the Ghost Hemp THC-P Live Resin Disposable. Offering 2 grams of a delta-8, THCP, and terpene blend, this THC-P disposable utilizes live resin, meaning the hemp plants are subject to flash freezing to aid in the preservation of natural essential oils, flavonoids, and terpenes from the hemp plant that are responsible for the unique flavors and aromas of the cannabis or hemp plant. The frozen plant matter is kept frozen throughout the extraction process and will carry over the flavor and aromas to the finished product. This gives a more true and full-bodied flavor than distillates.

We will update this blog post as more information emerges regarding THCP and its potential in the recreational and medical fields. With such a high binding affinity, that sole aspect is enough to warrant research into this new cannabinoid and its potential applications.